{"id":134,"date":"2026-09-22T13:06:32","date_gmt":"2026-09-22T13:06:32","guid":{"rendered":"https:\/\/funny-fermi.104-248-174-66.plesk.page\/?page_id=134"},"modified":"2026-10-29T11:36:42","modified_gmt":"2026-10-29T11:36:42","slug":"iir","status":"publish","type":"page","link":"https:\/\/funny-fermi.104-248-174-66.plesk.page\/fr\/iir\/","title":{"rendered":"IIR"},"content":{"rendered":"<main id='oxy-main'><div class=\"oxy-container-134-222 oxy-container od-page-iir\"><div class=\"oxy-container-134-221 oxy-container od-fx-793346c73\"><section class=\"oxy-container-134-235 oxy-container od-hero\" aria-labelledby=\"iir-title\"><div class=\"oxy-container-134-234 oxy-container od-container\"><div class=\"oxy-container-134-225 oxy-container od-hero-heading\"><div class=\"oxy-svg-icon2-134-223 oxy-svg-icon2 od-hero-icon od-iir-hero-icon\">\n<svg aria-hidden=\"true\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M15 14c.2-1 .7-1.7 1.5-2.5 1-.9 1.5-2.2 1.5-3.5A6 6 0 0 0 6 8c0 1 .2 2.2 1.5 3.5.7.7 1.3 1.5 1.5 2.5\"><\/path><path d=\"M9 18h6\"><\/path><path d=\"M10 22h4\"><\/path><\/svg>\n<\/div><h1 class=\"oxy-text-134-224 oxy-text od-hero-title\" id=\"iir-title\">\nInvestigator-Initiated Research\n<\/h1><\/div><p class=\"oxy-text-134-226 oxy-text od-hero-lead\">\nSupporting independent research initiatives in rare diseases\n<\/p><p class=\"oxy-text-134-227 oxy-text od-hero-copy\">\nOur IIR programme partners with independent researchers and academic institutions to advance scientific understanding and clinical outcomes in rare disease research. We provide support for innovative studies that align with our commitment to improving patient lives.\n<\/p><div class=\"oxy-container-134-230 oxy-container od-hero-actions\"><a class=\"oxy-text-link-134-228 oxy-text-link od-button od-button--accent od-button--borderless\" href=\"\/partnering\/\" target=\"_self\">\nPartnership Opportunities\n<\/a><a class=\"oxy-text-link-134-229 oxy-text-link od-button od-button--outlined-light\" href=\"\/pipeline\/\" target=\"_self\">\nOur Pipeline\n<\/a><\/div><button class=\"oxy-container-link-134-233 oxy-container-link od-hero-back od-iir-back\" target=\"_self\" data-interactions=\"[{&quot;trigger&quot;:&quot;click&quot;,&quot;prevent_default&quot;:true,&quot;actions&quot;:[{&quot;name&quot;:&quot;javascript_function&quot;,&quot;js_function_name&quot;:&quot;orphalanHeroBack&quot;}]}]\" id=\"iir-back\" type=\"button\" aria-label=\"Go back to the previous page\"><div class=\"oxy-svg-icon2-134-231 oxy-svg-icon2 od-hero-back-icon\">\n<svg aria-hidden=\"true\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"m15 18-6-6 6-6\"><\/path><\/svg>\n<\/div><span class=\"oxy-text-134-232 oxy-text od-link-label\">\nBack\n<\/span><\/button><\/div><\/section><section class=\"oxy-container-134-248 oxy-container od-section\" aria-labelledby=\"iir-community-title\"><div class=\"oxy-container-134-247 oxy-container od-container\"><header class=\"oxy-container-134-237 oxy-container od-iir-community-heading\"><span class=\"oxy-text-134-236 oxy-text od-eyebrow od-iir-eyebrow--flush\">\nWE INNOVATE\n<\/span><\/header><div class=\"oxy-container-134-246 oxy-container od-iir-community-grid\"><div class=\"oxy-container-134-242 oxy-container od-iir-community-copy\"><div class=\"oxy-container-134-238 oxy-container od-section-marker\" aria-hidden=\"true\"><\/div><h2 class=\"oxy-text-134-239 oxy-text od-section-title\" id=\"iir-community-title\">\nOur Work With the Medical Community\n<\/h2><p class=\"oxy-text-134-240 oxy-text od-iir-large-copy od-iir-large-copy--spaced\">\nAt Orphalan, we continuously engage with healthcare professionals and patient advocacy groups in our common goal of improving care and services for patients with rare disease. Together, by taking a patient-centric approach, in partnership with healthcare professionals, our mission is to collaborate to advance knowledge in rare disease and in particular to identify and find innovative solutions for the unmet needs of patients.\n<\/p><p class=\"oxy-text-134-241 oxy-text od-iir-large-copy\">\nOrphalan along with our network of Key Opinion Leaders strive to design meaningful and important studies to improve patient care and outcomes. It is through close collaborations with healthcare professionals and scientists, that Orphalan is able to address these unmet needs of patients with rare disease and potentially transform their lives through discovery and innovation.\n<\/p><\/div><figure class=\"oxy-container-134-245 oxy-container od-iir-community-media\"><img decoding=\"async\" class=\"oxy-image-134-243 oxy-image od-iir-community-image\" src=\"https:\/\/funny-fermi.104-248-174-66.plesk.page\/wp-content\/uploads\/2026\/09\/Together_1050.jpg\" alt=\"Patients and community connecting together\" loading=\"lazy\"><div class=\"oxy-container-134-244 oxy-container od-iir-community-shade\" aria-hidden=\"true\"><\/div><\/figure><\/div><\/div><\/section><section class=\"oxy-container-134-279 oxy-container od-section od-section--muted\" aria-labelledby=\"iir-definition-title\"><div class=\"oxy-container-134-278 oxy-container od-container od-iir-container\"><div class=\"oxy-container-134-249 oxy-container od-section-marker\" aria-hidden=\"true\"><\/div><h2 class=\"oxy-text-134-250 oxy-text od-section-title\" id=\"iir-definition-title\">\nWhat is Investigator-Initiated Research (IIR)?\n<\/h2><div class=\"oxy-container-134-277 oxy-container od-iir-definition-panel\"><p class=\"oxy-text-134-251 oxy-text od-iir-large-copy od-iir-large-copy--spaced\">\nAs part of our commitment to delivering innovative therapies to patients, Orphalan believes and values in the need to support ethically conducted independent clinical research by qualified third-party investigators.\n<\/p><p class=\"oxy-text-134-252 oxy-text od-iir-large-copy od-iir-large-copy--spaced\">\nOrphalan views scientific research produced by third party sponsors as complementary to Orphalan-sponsored research. Investigator initiated research (IIR) are studies with scientific and medical merit developed and sponsored by an independent investigator aligned with Orphalan's areas of interest or scientific priorities. These priorities are to help Orphalan to better understand the benefit\/risk profile of our therapies, as well as enabling us to explore new opportunities addressing unmet medical needs.\n<\/p><aside class=\"oxy-container-134-257 oxy-container od-iir-definition-callout\" aria-labelledby=\"iir-definition-label\"><header class=\"oxy-container-134-255 oxy-container od-iir-definition-heading\"><span class=\"oxy-text-134-253 oxy-text od-iir-definition-marker\" aria-hidden=\"true\">\n\n<\/span><h3 class=\"oxy-text-134-254 oxy-text od-iir-definition-label\" id=\"iir-definition-label\">\nDefinition\n<\/h3><\/header><p class=\"oxy-text-134-256 oxy-text od-body-small od-iir-strong\">\nAn IIR may be a clinical study conducted without the participation of Orphalan, for which the IIR sponsor requests Orphalan to provide either funding, drug product or both.\n<\/p><\/aside><div class=\"oxy-container-134-276 oxy-container od-iir-process\" aria-labelledby=\"iir-process-title\"><h3 class=\"oxy-text-134-258 oxy-text od-iir-process-title\" id=\"iir-process-title\">\nHow IIR Works\n<\/h3><ol class=\"oxy-container-134-275 oxy-container od-iir-process-grid\"><li class=\"oxy-container-134-262 oxy-container od-iir-process-step\"><span class=\"oxy-text-134-259 oxy-text od-iir-step-number\" aria-hidden=\"true\">\n1\n<\/span><h4 class=\"oxy-text-134-260 oxy-text od-iir-step-title\">\nResearcher Initiates\n<\/h4><p class=\"oxy-text-134-261 oxy-text od-iir-step-description\">\nAn independent investigator designs a study addressing a rare disease question\n<\/p><\/li><li class=\"oxy-container-134-266 oxy-container od-iir-process-step\"><span class=\"oxy-text-134-263 oxy-text od-iir-step-number\" aria-hidden=\"true\">\n2\n<\/span><h4 class=\"oxy-text-134-264 oxy-text od-iir-step-title\">\nProposal Submitted\n<\/h4><p class=\"oxy-text-134-265 oxy-text od-iir-step-description\">\nA formal proposal is sent to Orphalan outlining the study objectives and support required\n<\/p><\/li><li class=\"oxy-container-134-270 oxy-container od-iir-process-step\"><span class=\"oxy-text-134-267 oxy-text od-iir-step-number\" aria-hidden=\"true\">\n3\n<\/span><h4 class=\"oxy-text-134-268 oxy-text od-iir-step-title\">\nOrphalan Reviews\n<\/h4><p class=\"oxy-text-134-269 oxy-text od-iir-step-description\">\nOur team assesses scientific merit, ethical standards and alignment with our areas of interest\n<\/p><\/li><li class=\"oxy-container-134-274 oxy-container od-iir-process-step\"><span class=\"oxy-text-134-271 oxy-text od-iir-step-number od-iir-step-number--purple\" aria-hidden=\"true\">\n4\n<\/span><h4 class=\"oxy-text-134-272 oxy-text od-iir-step-title\">\nStudy Conducted\n<\/h4><p class=\"oxy-text-134-273 oxy-text od-iir-step-description\">\nThe investigator leads the research independently; Orphalan provides agreed funding or study drug\n<\/p><\/li><\/ol><\/div><\/div><\/div><\/section><section class=\"oxy-container-134-306 oxy-container od-section\" aria-labelledby=\"iir-areas-title\"><div class=\"oxy-container-134-305 oxy-container od-container od-iir-container\"><div class=\"oxy-container-134-280 oxy-container od-section-marker\" aria-hidden=\"true\"><\/div><h2 class=\"oxy-text-134-281 oxy-text od-section-title\" id=\"iir-areas-title\">\nAreas of Interest\n<\/h2><div class=\"oxy-container-134-304 oxy-container od-iir-areas-panel\"><p class=\"oxy-text-134-282 oxy-text od-iir-large-copy od-iir-large-copy--spaced\">\nOrphalan supports research projects related to our therapeutic products, diagnostic tests and disease of interest and that are aligned with our R&amp;D programs.\n<\/p><ul class=\"oxy-container-134-303 oxy-container od-iir-areas-grid\"><li class=\"oxy-container-134-287 oxy-container od-iir-area\"><div class=\"oxy-svg-icon2-134-283 oxy-svg-icon2 od-iir-area-icon\">\n<svg aria-hidden=\"true\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M21.801 10A10 10 0 1 1 17 3.335\"><\/path><path d=\"m9 11 3 3L22 4\"><\/path><\/svg>\n<\/div><div class=\"oxy-container-134-286 oxy-container od-iir-area-copy\"><h3 class=\"oxy-text-134-284 oxy-text od-iir-area-title\">\nWilson's Disease\n<\/h3><p class=\"oxy-text-134-285 oxy-text od-iir-area-description\">\nResearch related to copper metabolism disorders and chelation therapy\n<\/p><\/div><\/li><li class=\"oxy-container-134-292 oxy-container od-iir-area\"><div class=\"oxy-svg-icon2-134-288 oxy-svg-icon2 od-iir-area-icon\">\n<svg aria-hidden=\"true\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M21.801 10A10 10 0 1 1 17 3.335\"><\/path><path d=\"m9 11 3 3L22 4\"><\/path><\/svg>\n<\/div><div class=\"oxy-container-134-291 oxy-container od-iir-area-copy\"><h3 class=\"oxy-text-134-289 oxy-text od-iir-area-title\">\nInfantile Spasms (West's Syndrome)\n<\/h3><p class=\"oxy-text-134-290 oxy-text od-iir-area-description\">\nWest's syndrome and epilepsy research\n<\/p><\/div><\/li><li class=\"oxy-container-134-297 oxy-container od-iir-area\"><div class=\"oxy-svg-icon2-134-293 oxy-svg-icon2 od-iir-area-icon\">\n<svg aria-hidden=\"true\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M21.801 10A10 10 0 1 1 17 3.335\"><\/path><path d=\"m9 11 3 3L22 4\"><\/path><\/svg>\n<\/div><div class=\"oxy-container-134-296 oxy-container od-iir-area-copy\"><h3 class=\"oxy-text-134-294 oxy-text od-iir-area-title\">\nGlioblastoma\n<\/h3><p class=\"oxy-text-134-295 oxy-text od-iir-area-description\">\nResearch in rare brain tumours including glioblastoma\n<\/p><\/div><\/li><li class=\"oxy-container-134-302 oxy-container od-iir-area\"><div class=\"oxy-svg-icon2-134-298 oxy-svg-icon2 od-iir-area-icon\">\n<svg aria-hidden=\"true\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M21.801 10A10 10 0 1 1 17 3.335\"><\/path><path d=\"m9 11 3 3L22 4\"><\/path><\/svg>\n<\/div><div class=\"oxy-container-134-301 oxy-container od-iir-area-copy\"><h3 class=\"oxy-text-134-299 oxy-text od-iir-area-title\">\nDiagnostic Innovation\n<\/h3><p class=\"oxy-text-134-300 oxy-text od-iir-area-description\">\nNovel diagnostic tests for rare diseases\n<\/p><\/div><\/li><\/ul><\/div><\/div><\/section><section class=\"oxy-container-134-327 oxy-container od-section\" aria-labelledby=\"iir-impact-title\"><div class=\"oxy-container-134-326 oxy-container od-container od-iir-container\"><header class=\"oxy-container-134-308 oxy-container od-iir-impact-heading\"><span class=\"oxy-text-134-307 oxy-text od-eyebrow od-iir-eyebrow--flush\">\nOUR IMPACT\n<\/span><\/header><h2 class=\"oxy-text-134-309 oxy-text od-section-title od-iir-impact-title\" id=\"iir-impact-title\">\nIIR Program Impact\n<\/h2><p class=\"oxy-text-134-310 oxy-text od-iir-impact-lead\">\nSince the launch of our IIR programmeme, Orphalan has supported independent investigators across multiple countries and therapeutic areas, contributing to the generation of real-world evidence in rare diseases.\n<\/p><div class=\"oxy-container-134-323 oxy-container od-iir-stats-grid\"><article class=\"oxy-container-134-314 oxy-container od-iir-stat-card\"><span class=\"oxy-text-134-311 oxy-text od-iir-stat-number\">\n15+\n<\/span><h3 class=\"oxy-text-134-312 oxy-text od-iir-stat-label\">\nActive Studies\n<\/h3><p class=\"oxy-text-134-313 oxy-text od-iir-stat-description\">\nOngoing investigator-led research projects\n<\/p><\/article><article class=\"oxy-container-134-318 oxy-container od-iir-stat-card\"><span class=\"oxy-text-134-315 oxy-text od-iir-stat-number od-iir-stat-number--purple\">\n30+\n<\/span><h3 class=\"oxy-text-134-316 oxy-text od-iir-stat-label\">\nPrincipal Investigators\n<\/h3><p class=\"oxy-text-134-317 oxy-text od-iir-stat-description\">\nLeading researchers and clinicians worldwide\n<\/p><\/article><article class=\"oxy-container-134-322 oxy-container od-iir-stat-card\"><span class=\"oxy-text-134-319 oxy-text od-iir-stat-number od-iir-stat-number--navy\">\n8\n<\/span><h3 class=\"oxy-text-134-320 oxy-text od-iir-stat-label\">\nCountries\n<\/h3><p class=\"oxy-text-134-321 oxy-text od-iir-stat-description\">\nInternational reach across Europe and beyond\n<\/p><\/article><\/div><aside class=\"oxy-container-134-325 oxy-container od-iir-impact-disclaimer\" aria-label=\"Independent research disclaimer\"><p class=\"oxy-text-134-324 oxy-text od-body-small od-iir-strong\">\nIIR studies supported by Orphalan are conducted independently by the sponsoring investigator. Orphalan may provide funding, investigational product or both, in accordance with applicable regulations and internal policies. All supported studies are subject to scientific and ethical review. Results from IIR studies are the sole responsibility of the investigator and do not necessarily reflect the views of Orphalan.\n<\/p><\/aside><\/div><\/section><section class=\"oxy-container-134-335 oxy-container od-section od-iir-contact\" aria-labelledby=\"iir-contact-title\"><div class=\"oxy-container-134-334 oxy-container od-container od-iir-contact-container\"><span class=\"oxy-text-134-328 oxy-text od-eyebrow\">\nWE PARTNER\n<\/span><h2 class=\"oxy-text-134-329 oxy-text od-iir-contact-title\" id=\"iir-contact-title\">\nInterested in Collaborating?\n<\/h2><p class=\"oxy-text-134-330 oxy-text od-iir-large-copy od-iir-contact-body\">\nWe welcome proposals from qualified investigators in rare disease research. To learn more about our IIR programmeme or to submit a proposal, please contact our team.\n<\/p><div class=\"oxy-container-134-333 oxy-container od-iir-contact-actions\"><a class=\"oxy-text-link-134-331 oxy-text-link od-button od-home-control od-home-control--navy od-home-control--semibold\" href=\"\/contact\/\" target=\"_self\">\nContact Us\n<\/a><a class=\"oxy-text-link-134-332 oxy-text-link od-button od-home-control od-home-control--subtle\" href=\"\/pipeline\/\" target=\"_self\">\nView Our Pipeline\n<\/a><\/div><\/div><\/section><aside class=\"oxy-container-134-343 oxy-container od-approval-strip\" aria-label=\"Content approval information\"><div class=\"oxy-container-134-342 oxy-container od-container\"><div class=\"oxy-container-134-341 oxy-container od-approval-layout\"><div class=\"oxy-container-134-339 oxy-container od-approval-code\"><span class=\"oxy-text-134-336 oxy-text od-approval-text\">\nMLR Approval Code: ORP-EU-2026-001\n<\/span><span class=\"oxy-text-134-337 oxy-text od-approval-text\" aria-hidden=\"true\">\n\u2022\n<\/span><span class=\"oxy-text-134-338 oxy-text od-approval-text\">\nApproved: October 2026\n<\/span><\/div><p class=\"oxy-text-134-340 oxy-text od-approval-text\">\nFor Healthcare Professionals and Patients in Europe and regions where Orphalan operates\n<\/p><\/div><\/div><\/aside><\/div><\/div><\/main>","protected":false},"excerpt":{"rendered":"<p>Investigator-Initiated Research Supporting independent research initiatives in rare diseases Our IIR programme partners with independent researchers and academic institutions to advance scientific understanding and clinical outcomes in rare disease research. We provide support for innovative studies that align with our commitment to improving patient lives. Partnership Opportunities Our Pipeline Back WE INNOVATE Our Work With [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_oxygen_hide_in_design_set":false,"_oxygen_tags":"","footnotes":""},"class_list":["post-134","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/funny-fermi.104-248-174-66.plesk.page\/fr\/wp-json\/wp\/v2\/pages\/134","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/funny-fermi.104-248-174-66.plesk.page\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/funny-fermi.104-248-174-66.plesk.page\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/funny-fermi.104-248-174-66.plesk.page\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/funny-fermi.104-248-174-66.plesk.page\/fr\/wp-json\/wp\/v2\/comments?post=134"}],"version-history":[{"count":15,"href":"https:\/\/funny-fermi.104-248-174-66.plesk.page\/fr\/wp-json\/wp\/v2\/pages\/134\/revisions"}],"predecessor-version":[{"id":602,"href":"https:\/\/funny-fermi.104-248-174-66.plesk.page\/fr\/wp-json\/wp\/v2\/pages\/134\/revisions\/602"}],"wp:attachment":[{"href":"https:\/\/funny-fermi.104-248-174-66.plesk.page\/fr\/wp-json\/wp\/v2\/media?parent=134"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}